Release Date: August 25, 2008
Valid Through Date: August 24, 2009

Target Audience
Primary care physicians and other healthcare professionals who have a special interest in the diagnosis, management and treatment of neurological, musculoskeletal and vascular disorders that present in the lower extremities.
These educational activities are conducted as a part of the Biology of Leg Disorders educational initiative (BOLD^®), sponsored by Professional Postgraduate Services^®, Secaucus, NJ.

Professional Postgraduate Services^® is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

These educational activities are supported by an educational grant from AR Scientific, Inc.

Peer Reviewer Disclosure
These activities were peer reviewed by CME Peer Review, LLC, which has no relevant financial relationships to disclose.

Disclosure
Some of the material included in these activities may contain off-label or investigational uses of products. This material will be identified with an asterisk [*].

Faculty Disclosures

Paul P. Doghramji, MD, is Medical Director of Health Services at Ursinus College in Collegeville and Assistant Medical Director for Health Services at Hill School in Pottstown, both in Pennsylvania. Dr Doghramji has indicated the following relevant financial relationships: speaker for Cephalon, Inc., Pfizer Inc, sanofi-aventis, Sepracor Inc., and Takeda Pharmaceuticals North America, Inc.

Joseph A. Lieberman III, MD, MPH, is a Professor of Family Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia, Pennsylvania. Dr Lieberman has indicated the following relevant financial relationships: retained consultant for sanofi-aventis, Neurocrine Biosciences, Takeda Pharmaceuticals North America, Inc., and Wyeth; speaker for Takeda Pharmaceuticals North America, Inc.

Emile R. Mohler III, MD, is an Associate Professor of Medicine at the University of Pennsylvania School of Medicine and Director of Vascular Medicine at the University of Pennsylvania Health System in Philadelphia. Dr Mohler has indicated the following relevant financial relationships: speaker for sanofi-aventis/Bristol-Myers Squibb, Merck & Co., Inc., and AstraZeneca; grant/research support from sanofi-aventis/Bristol-Myers Squibb and GlaxoSmithKline.

Michael P. Rosenthal, MD, is Professor and Vice Chair for Academic Programs in the Department of Family and Community Medicine of Jefferson Medical College and an Attending Physician at Thomas Jefferson University Hospital in Philadelphia, Pennsylvania. Dr Rosenthal has indicated the following relevant financial relationships: grant/research support from and speakers for Endo Pharmaceuticals Inc.; advisory committee member for Abbott Pharmaceuticals and Endo Pharmaceuticals Inc.

John S. Sundy, MD, PhD, is an Associate Professor of Medicine at Duke University School of Medicine in Durham, North Carolina. Dr Sundy has indicated the following relevant financial relationships: retained consultant for Ardea Biosciences, Genentech, Novartis, and Regeneron; stockholder for General Electric; grant/research support from Savient Pharmaceuticals, Inc., Mannkind Corporation, GlaxoSmithKline, and Regeneron.

Michael J. Thorpy, MD, is a professor of neurology at the Albert Einstein College of Medicine and Director of the Sleep-Wake Disorders Center at Montefiore Medical Center in Bronx, New York. Dr Thorpy has indicated the following relevant financial relationships: speaker for GlaxoSmithKline and Boehringer Ingelheim GmbH.

PPS Staff Disclosures
Executive Editor Genevieve Blazini; Scientific Director Luciano Passador, PhD; Senior Editor Jennifer Nisita; Senior Program Director Vanessa Saullo; CME Program Manager Wadee'ah Terry; and CME Director Elizabeth Ward have no relevant financial relationships to disclose

System Requirements
WINDOWS PC SYSTEM REQUIREMENTS: 266-MHz Pentium II; Windows 98 or higher; 64 MB RAM; 800 x 600 screen resolution set for "High Color (16-Bit)"; Macromedia Flash Player 6 or higher.
MACINTOSH^® SYSTEM REQUIREMENTS: Power Mac g3 at 300 MHz; System 8.5 or higher (excluding Mac OSX); 96 MB RAM; 20 MB minimum hard disk space available; 800 x 600 screen resolution set to "Thousands of Colors"; Macromedia Flash player 6 or higher.